
一、个人基本情况
高田,女,1993.06,河南永城,中共党员,博士研究生(2022年毕业于中国科学技术大学纳米技术与纳米仿生学院细胞生物学专业),生物与食品学院生物科学专业教师,讲师,办公地址(睢阳校区生物与食品学院科技楼103室)。主持项目3项,参与项目6项;已发表SCI论文20余篇,其中一作和共通讯作者论文共9篇;申请发明专利9项,其中授权4项。
二、教育经历和工作经历
2012.09~2016.06,山东大学,药学专业,理学学士
2016.09~2022.06,中国科学技术大学,细胞生物学专业,理学博士
2022.07~2024.12,中国科学院苏州纳米技术与纳米仿生研究所,博士后
2025.01~2025.12,中国科学院苏州纳米技术与纳米仿生研究所,副研究员
2026.01~至 今,商丘师范学院
三、主讲课程
主讲《细胞生物学专题》课程
四、承担项目
1.国家自然科学基金青年基金(22307137),编号基于适配体识别的外泌体特征蛋白的量化分析及其用于肝癌早期诊断的研究,2024.01~2026.12,30万,主持
2.中国博士后基金面上项目(2023M732555),生基于适配体标记的外泌体表面蛋白的量化分析及其用于肝癌早期检测的研究,2023.09~2025.08,8万,主持
3.江苏省卓越博士后计划项目(2023ZB685),细胞外囊泡表面特征蛋白的量化分析用于肿瘤精准诊疗,2023.01~2024.12,30万,主持
4.国家自然科学基金面上项目(32471464),单细胞分辨率的高通量活细胞lncRNA-RBP相互作用检测技术及对肿瘤耐药异质性的研究,2025.01~2028.12,50万,主要参与
5.中国科学院苏州纳米技术与纳米仿生研究所创新培育专项,类器官制造及药物筛选研究,2023.07~2025.06,1350万,主要参与
6.江苏省优秀青年基金项目(BK20220099),肝癌不同细胞外囊泡亚群的定量分析及其在肝癌早期检测的应用,2022.07-2025.06,50万,参与
7.江苏省重点严打计划(BE2020766),长循环和肿瘤靶向的原位生物发光激发的MOFs纳米光敏剂的构建及用于大肠癌的动力学治疗技术研发,2021.01-2023.06,50万,参与
8.国家自然科学基金面上项目(32071392),肿瘤微环境刺激响应的原位生物发光激发的MOFs纳米光敏剂体系的构建及应用研究,2021.01~2024.12,58万,参与
五、发表论文
1.Ying-Tzu Yen#; Chen Zhao#; Tian Gao#; Anmin Wang; Ning Kang; Jiahui Pu; Jacqueline Ziqian Yang; Qixin Hu; Hyoyong Kim; Junseok Lee; Ryan Y. Zhang; Na Liu; You-Ren Ji; Yong Ju; Lynn Zheng; James Lee-South; Vivian Xufei Zuo; Audrey Qian; Aaron Kwan; Yating Zhang; Shenghua Zhang; Zhili Wang; Jing Ren; Huaichao Liu; Zihan Wang; Yang Yue; Jina Kim; Jennifer Sun; Gabriella A. DiBernardo; Laura B. James-Allan; Ying Chen; Wenpei Zhu; Wenyuan Guo; Renjun Pei; Sanaz Memarzadeh; Sungyong You; B.J. Rimel; Kate Lawrenson; Beth Y. Karlan; Myung-Shin Sim; Shaohua Lu*; Jipeng Wan*; Na Sun*; Hsian-Rong Tseng*; Yazhen Zhu*. Tumor extracellular vesicle surface protein-mRNA integration assay for early detection of epithelial ovarian cancer. eBioMedicine, 2025, 119, 105884.
2.Wenjuan Xu, Qingyang Liu, Na Sun*, Tian Gao*, Renjun Pei*. Protein-targeted aptamers in liquid biopsy: from efficient screening to precise cancer diagnosi6. Analyst, 2026, 151(2): 275-299.
3.Wenjing Li, Tian Gao*, Renjun Pei*. Selection of trophoblast cell surface antigen 2-targeted aptamer for the development of cytotoxic aptamer-drug conjugate. International Journal of Biological Macromolecules, 2024, 279, 125456.
4.Tian Gao, Wenjing Li, Jialing Ma, Ying Chen, Zhili Wang, Na Sun, Renjun Pei*. Selection of DNA aptamer recognizing CD44 for high-efficiency capture of circulating tumor cells. Talanta, 2023, 262, 124728.
5.Tian Gao, Zheng Mao, Wenjing Li, Renjun Pei*. Anti-PD-L1 DNA aptamer antagonizes the interaction of PD-1/PD-L1 with antitumor effect. Journal of Materials Chemistry B, 2021, 9, 746-756.
6.Tian Gao#, Pi Ding#, Wenjing Li, Zhili Wang*, Qiao Lin, Renjun Pei*. Isolation of DNA aptamers targeting N-cadherin and high-efficiency capture of circulating tumor cells by using dual aptamers. Nanoscale, 2020, 12, 22574-22585.
7.Tian Gao, Yu Luo, Wenjing Li, Yanwei Cao*, Renjun Pei*. Progress in isolation of aptamers to light-up the dyes and the applications. Analyst, 2020, 145, 701-708.
8.Tian Gao, Renjun Pei*. Isolation of DNA aptamer targeting PD-1 with an antitumor immunotherapy effect. ACS Applied Bio Materials, 2020, 3, 7080-7086.
9.Jine Wang+, Tian Gao+, Yu Luo, Zhili Wang, Yajie Zhang, Ye Zhang, Yuanyuan Zhang*, Renjun Pei*. In vitro selection of DNA aptamers by cell-SELEX as a molecular probe for cervical cancer recognition and imaging. Journal of Molecular Evolution, 2019, 87, 72-82.
10.Binyao Liu, Yaning Liu, Lei Qiu, Tian Gao, Na Sun, Yecheng Li, Renjun Pei, Haihang Ye, Tingrui Pan, Deterministic evolution of aptamers via a microfluidic-integrated robotic platform using complex exosomes as targets, ACS Nano, 2026, 20(7): 5476-5488.
11.Xiaona Fang, Tian Gao, Zhaofeng Luo* Renjun Pei*. Efficient selection of vancomycin-specific aptamers via particle display and development of a high-sensitivity fluorescent apta-sensor for vancomycin detection. Sensors and Actuators B: Chemical, 2025,436, 137681.
12.Xiaona Fang, Wenjing Li, Tian Gao, Qurat Ul Ain Zahrac, Zhaofeng Luo*, Renjun Pei*. Rapid screening of aptamers for fluorescent targets by integrated digital PCR and flow cytometry. Talanta, 2022, 242, 123302.
13.Wenjing Li, Zheng Wang, Tian Gao, Shengkai Sun, Mingsheng Xu, Renjun Pei*. Selection of CD133 targeted DNA aptamers for the efficient and specific therapy of colorectal cancer. Journal of Materials Chemistry B, 2022, 10, 2057-2066.
14.Jincong Yan, Tian Gao, Zhongzhong Lu, Jingbo Yin, Ye Zhang*, Renjun Pei*. Aptamer-targeted photodynamic platforms for tumor therapy. ACS Applied Materials & Interfaces, 2021, 13,27749-27773.
15.Yanwei Cao, Wenjing Li, Tian Gao, Pi Ding and Renjun Pei*. Oneterminalguanosineflip ofintramolecularparallel G-quadruplex:catalyticenhancement of G-quadruplex/Hemin DNAzymes. Chemical Engineering Journal, 2020, 26, 8631-8638.
六、授权专利
1.裴仁军,高田,基于工程化细胞的N-cadherin核酸适配体的筛选及应用,ZL201910553457.8
2.裴仁军,高田,PD-L1核酸适配体、其筛选方法及应用,ZL202010428757.6
3.裴仁军,高田,PD-1核酸适配体、其筛选方法及应用,ZL202010428756.1
4.裴仁军,高田,膜蛋白靶标CD44的核酸适配体、其筛选方法与应用,ZL202210714769.4
七、获得奖励
1.2024年 中国科学院苏州纳米所,先进工作者
2.2023年 中国科学院苏州纳米所,优秀博士后计划
3.2023年 中国科学院苏州纳米技术所,青年学术奖
4.2022年 中国科学院南京分院,院长优秀奖
5.2022年 中国科学技术大学,优秀毕业生